Propanol, 1(or 2)- (2-methoxymethylethoxy)-, acetate
CASRN#
88917-22-0
INCI Name
PPG-2 METHYL ETHER ACETATE
Alternate Names
DPMA, 1-(3-Methoxypropoxy)propyl acetate, Glycol Ether DPM Acetate, 1(or2)-(2methoxymethylethoxy)-propanoacetate, propanol,1(or2)-(2-methoxymethylethoxy)-,acetate, PPG-2 Methyl Ether Acetate
Common Trade Names
DPMAc, Dowanol DPMA
Molecular Weight
1.9E+2 g/mol
Functional Uses
Solvent, fragrance, film-forming agent, coalescing agent
Common Impurities
-
Is this a VOC?
Yes
Is this an exempt VOC?
No
Vapor Pressure
0.13 mm Hg
Octanol-water partition coefficient (log Kow)
0.803
Solubility at 25 C
1.94E+5 mg/l
Boiling Point
209 °C
Particle size range as aerodynamic diameter
- - - μm
Hazard Summary
C2C Chemical Rating
b
GHS Health
None
GHS Enviro
None
Assessed by
U.S. EPA Low Priority Chemical report.
Assessment Date
Apr 20, 2020
Assessment Expires
Apr 19, 2025
Verification Status
verified
Executive Summary
DPMA is a propylene oxide-based, or P-series, glycol ether acetate. DPMA is an organic chemical compound that contains an ester functional group comprised of two alkyl groups connected by a carbonyl and a linking oxygen atom (RCOOR’) and two ether functional groups--an oxygen atom connected two alkyl groups (R-O-R’). DPMA is commercially produced as a mixture of four isomeric components in which the internal ether linkage may be adjacent to either a primary or secondary carbon atom. Shorter chain ethers and esters, such as DPMA, are liquids capable of dissolving other substances and typically function as solvents. DPMA is a colorless, water-soluble, sweet-smelling liquid with a moderate evaporation rate, and it is miscible with organic solvents. These properties make DPMA useful as a solvent, fragrance, film-forming agent, and coalescing agent in a variety of applications and product sectors. Section 5 includes conditions of use for this chemical.
Hazard Tables

How to read the GHS Hazard Summary Table

 
Carcinogenicity
Mutagenicity
Reproductive Toxicity
Developmental Toxicity
Acute Toxicity
STOT-Single
STOT-Repeated
STOT- Neurotoxicity-Single
STOT- Neurotoxicity-Repeated
Skin Sensitizer
Respiratory Sensitizer
Skin Corrosion/Irritation
Serious Eye Damage/Eye Irritation
Acute Aquatic Toxicity
Chronic Aquatic Toxicity
Ozone Depletion
Oral
Dermal
Inhalation
NC
Rationale
Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data.
NC
Rationale
Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data.
NC
Rationale
Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data.
NC
Rationale
Weight of evidence indicates low concern for inducing genotoxicity.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for reproductive toxicity.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
Data not available.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity.
NC
Rationale
Multiple studies indicating low-concern of acute toxicity.
NC
Rationale
Multiple studies indicating low-concern of acute toxicity.
NC
Rationale
Findings in one study indicating low-concern of acute toxicity.
CNP
Rationale
No data available.
NC
Rationale
No adverse effects at high dose exposure after a single dose.
NC
Rationale
No data available.
NC
Rationale
Study findings indicating low-concern of toxicity from repeated exposure.
NC
Rationale
Weight of evidence across multiple studies suggest findings indicate low concern for repeated dermal exposure.
NC
Rationale
Findings in one study indicating low-concern after repeat dosing.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
No guideline neurotoxicity studies on DPMA or closely-related analogs were available to assess the potential for DPMA to cause neurotoxicity. DPMA’s low-concern findings for other human health hazard endpoints, including toxicity from acute and repeated exposures, and predictions by ToxCast, provide sufficient information to indicate low concern for neurotoxicity.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.
NC
Rationale
No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.
NC
Rationale
Multiple studies indicate low concern for skin irritation.
NC
Rationale
Multiple studies indicate low concern for eye irritation.
NC
Rationale
Aquatic toxicity results provide sufficient information to indicate low concern for acute aquatic exposure by exceeding the low-concern benchmark of 10 mg/L.
NC
Rationale
ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.
NC
Rationale
Chemical is not listed as an ozone depletor according to the Montreal Protocol or a greenhouse gas according to IPCC report.
Other
  • Explosives: Not classified
  • Flammable Gases: Not classified
  • Aerosols: Not classified
  • Oxidizing Gases: Not classified
  • Flammable Liquids: Category 4
  • Flammable Solids: Not classified
  • Self-reactive substances and mixtures: Not classified
  • Pyrophoric Liquids: Not classified
  • Pyrophoric Solids: Not classified
  • Self-heating Substances and Mixtures: Not classified
  • Substances and Mixtures which in contact with water, emit flammable gases: Not classified
  • Oxidizing Liquids: Not classified
  • Oxidizing Solids: Not classified
  • Organic Peroxides: Not classified
  • Corrosive to Metals: Not classified
  • Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health
Environmental
Other
 
Carcinogenicity
Mutagenicity
Reproductive & Developmental Toxicity
Endocrine Activity / Disruption
Oral Toxicity
Dermal Toxicity
Inhalation Toxicity
Neurotoxicity
Skin, Eye, and Respiratory Corrosion/Irritation
Sensitization of Skin and Airways
Fish Toxicity
Daphnia Toxicity
Algae Toxicity
Terrestrial Toxicity
Persistence
Bioaccumulation
Climatic Relevance
Other (Human Health)
Organohalogens
Toxic Metals
Other (Environmental Health)
Oral
Dermal
Inhalation
-
-
-
G
G
G
G
-
Rationale
No data available.
G
G
G
G
-
-
G
G
G
G
G
-
Y
Rationale
No degradation products of concern were identified for this chemical substance. Based on the reasonably available information and weight of the scientific evidence, sufficient information indicates that this chemical will have low persistence.
G
Rationale
Based on the estimated bioaccumulation factor (BAF) value of 1.1, using Estimation Programs Interface (EPI) Suite models, indicates a low potential for bioaccumulation in the environment based on the low-concern threshold of less than 1000.
Y
G
Rationale
No data available
G
G
G
Rationale
No data available.