Propanol, [2-(2-butoxymethylethoxy)methylethoxy]-
CASRN#
55934-93-5
INCI Name
PPG-3 BUTYL ETHER
Alternate Names
Tripropylene glycol butyl ether
Common Trade Names
DOWANOL TPnB Glycol Ether; TPnB
Molecular Weight
248.4 g/mol
Functional Uses
Solvent, coalescing agent, film-forming agent
Common Impurities
-
Is this a VOC?
No
Is this an exempt VOC?
No
Vapor Pressure
0.00308 mm Hg
Octanol-water partition coefficient (log Kow)
1.9
Solubility at 25 C
4.02E+4 mg/l
Boiling Point
274 °C
Particle size range as aerodynamic diameter
- - - μm
Hazard Summary
C2C Chemical Rating
c/b
GHS Health
H316H320
GHS Enviro
None
Assessed by
U.S. EPA Low Priority Chemical report.
Assessment Date
Jul 10, 2020
Assessment Expires
Jul 9, 2025
Verification Status
verified
Executive Summary
Tripropylene glycol n-butyl ether (TPnB) is a P-series glycol ether, meaning that it is made from propylene oxide. Glycol ethers are organic chemical compounds that contain both an alcohol functional group (R-OH) and an ether functional group, which is an oxygen atom connected to two alkyl groups (RO-R’). TPnB is a linear molecule that can be composed of three isomeric propylene oxide groups linked together through ether groups, terminating in a n-butyl carbon chain on one end and an alcohol on the other. Shorter chain ethers and esters, such as TPnB, are liquids capable of dissolving other substances and typically function as solvents. TPnB is a colorless to light yellow hydrophobic liquid with a high boiling point and low volatility. These properties make TPnB a useful solvent, coalescing agent, and filmforming agent in a variety of applications and product sectors.
Hazard Tables

How to read the GHS Hazard Summary Table

 
Carcinogenicity
Mutagenicity
Reproductive Toxicity
Developmental Toxicity
Acute Toxicity
STOT-Single
STOT-Repeated
STOT- Neurotoxicity-Single
STOT- Neurotoxicity-Repeated
Skin Sensitizer
Respiratory Sensitizer
Skin Corrosion/Irritation
Serious Eye Damage/Eye Irritation
Acute Aquatic Toxicity
Chronic Aquatic Toxicity
Ozone Depletion
Oral
Dermal
Inhalation
NC
Rationale
Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Weighing the negative results in several cell lines with the positive results occurring only at cytotoxic concentrations, EPA interprets these results to indicate DPMA has low concern for inducing genotoxicity.
NC
Rationale
No adverse effects observed in a one-generation reproductive study indicate low concern for reproductive toxicity.
CNP
Rationale
Data not available.
CNP
Rationale
Data not available.
CNP
Rationale
Data not available.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity from dermal exposures.
NC
Rationale
Several studies indicate low concern for developmental toxicity from vapor and aerosol exposures to tripropylene glycol n-butyl ether.
NC
Rationale
Several studies indicate low concern for acute toxicity from oral exposures.
NC
Rationale
An OECD Guideline 402 study indicates low concern for acute toxicity from dermal exposures.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for acute toxicity from inhalation exposures.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
Several studies indicate low concern for repeated dose toxicity from oral exposures.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for repeated dose toxicity from dermal exposures.
NC
Rationale
Lower confidence due to analog data. Analog data indicate low concern for repeated dose toxicity from inhalation exposures.
CNP
Rationale
Data not available.
CNP
Rationale
Data not available.
CNP
Rationale
Data not available.
NC
Rationale
Relevant endpoints measured in a repeated dose study and in vitro high throughout biochemical-and cell-based assays related to neurological functions indicate low concern for neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available.
NC
Rationale
In vitro high throughout biochemical-and cell-based assays related to neurological functions to indicate low concern for neurotoxicity. Lower confidence due to use of new approach methodologies (NAMs).
NC
Rationale
In vitro high throughout biochemical-and cell-based assays related to neurological functions indicate low concern for neurotoxicity. Lower confidence due to use of new approach methodologies (NAMs).
NC
Rationale
No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.
NC
Rationale
No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification. The weight of scientific evidence provides sufficient information to indicate low concern for respiratory sensitization.
Cat 3
Rationale
Lower confidence due to analog data. Analog data indicates low severity and reversibility (assigned category 3) for skin irritation.
Cat 2B
Rationale
Mixed results indicate moderate concern (assigned category 2B) for eye irritation.
NC
Rationale
Studies on aquatic vertebrates, invertebrates, and algae indicate low concern for acute exposure.
NC
Rationale
ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.
NC
Rationale
Chemical is not on Montreal Protocol or IPCC list.
Other
  • Explosives: Not classified
  • Flammable Gases: Not classified
  • Aerosols: Not classified
  • Oxidizing Gases: Not classified
  • Flammable Liquids: Not classified
  • Flammable Solids: Not classified
  • Self-reactive substances and mixtures: Not classified
  • Pyrophoric Liquids: Not classified
  • Pyrophoric Solids: Not classified
  • Self-heating Substances and Mixtures: Not classified
  • Substances and Mixtures which in contact with water, emit flammable gases: Not classified
  • Oxidizing Liquids: Not classified
  • Oxidizing Solids: Not classified
  • Organic Peroxides: Not classified
  • Corrosive to Metals: Not classified
  • Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health
Environmental
Other
 
Carcinogenicity
Mutagenicity
Reproductive & Developmental Toxicity
Endocrine Activity / Disruption
Oral Toxicity
Dermal Toxicity
Inhalation Toxicity
Neurotoxicity
Skin, Eye, and Respiratory Corrosion/Irritation
Sensitization of Skin and Airways
Fish Toxicity
Daphnia Toxicity
Algae Toxicity
Terrestrial Toxicity
Persistence
Bioaccumulation
Climatic Relevance
Other (Human Health)
Organohalogens
Toxic Metals
Other (Environmental Health)
Oral
Dermal
Inhalation
-
-
-
G
G
G
G
-
Rationale
No data available.
G
G
G
G
-
-
Y
G
G
G
G
-
G
Rationale
The available biodegradation results meet the low-concern threshold and indicate this chemical will have low persistence.
G
Rationale
Based on the estimated BAF value of 6.22, using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that tripropylene glycol n-butyl ether has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.
G
G
Rationale
No data available.
G
G
G
Rationale
No data available.