1-Butanol, 3-methoxy-, 1-acetate
CASRN#
4435-53-4
INCI Name
Alternate Names
3-METHOXYBUTYL ACETATE, Butoxyl, Acetic Acid 3-Methoxybutyl Ester, 1-Butanol, 3-methoxy-, acetate, Acetic acid, 3-methoxybutyl ester
Common Trade Names
Butoxyl
Molecular Weight
146.19 g/mol
Functional Uses
Solvent
Common Impurities
-
Is this a VOC?
Yes
Is this an exempt VOC?
No
Vapor Pressure
0.44 mm Hg
Octanol-water partition coefficient (log Kow)
1.01
Solubility at 25 C
4.6E+3 mg/l
Boiling Point
135 °C
Particle size range as aerodynamic diameter
- - - μm
Hazard Summary
C2C Chemical Rating
grey/c
GHS Health
H320
GHS Enviro
H402
Assessed by
U.S. EPA Low Priority Chemical report.
Assessment Date
Jul 10, 2020
Assessment Expires
Jul 9, 2025
Verification Status
verified
Executive Summary
3-Methoxybutyl acetate is an organic chemical compound that contains both an ester functional group, which is a pair of alkyl groups connecting by a carbonyl and a linking oxygen atom (RCOOR), and an ether functional group, which is an oxygen atom connected two alkyl groups (R-O-R). Shorter chain ethers and esters typically function as solvents, which are liquids capable of dissolving other substances. 3-Methoxybutyl acetate is water soluble and miscible with common organic solvents. These properties make 3-methoxybutyl acetate ideal for use as a solvent in a variety of applications and product sectors.
Hazard Tables

How to read the GHS Hazard Summary Table

 
Carcinogenicity
Mutagenicity
Reproductive Toxicity
Developmental Toxicity
Acute Toxicity
STOT-Single
STOT-Repeated
STOT- Neurotoxicity-Single
STOT- Neurotoxicity-Repeated
Skin Sensitizer
Respiratory Sensitizer
Skin Corrosion/Irritation
Serious Eye Damage/Eye Irritation
Acute Aquatic Toxicity
Chronic Aquatic Toxicity
Ozone Depletion
Oral
Dermal
Inhalation
NC
Rationale
Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.
NC
Rationale
Negative results for mutagenicity tests indicate low concern for genotoxicity.
NC
Rationale
Lower confidence due to combined repeated dose toxicity study with reproduction toxicity screening. No reproductive effects on mating, fertility, and estrus cycle indicate low concern for reproductive toxicity.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
No adverse effects observed in a prenatal development study indicate low concern for developmental toxicity.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
Lower confidence due to weight of evidence using data from 3-methoxybutyl acetate and an analog to indicate low concern for acute toxicity.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
A 28-day repeated dose study indicated no adverse effects at the low-concern threshold.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
Relevant endpoints measured in a repeated dose study to indicate low concern for neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available.
CNP
Rationale
No data available.
CNP
Rationale
No data available.
NC
Rationale
No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.
NC
Rationale
No structural alerts identified for respiratory sensitization. The results from these NAMs and weight of the scientific evidence provide sufficient information to indicate low concern for respiratory sensitization.
NC
Rationale
Lower confidence due to analog data. Analog data indicates low concern for skin irritation.
Cat 2B
Rationale
Effects that were fully reversible within 48-hours indicate moderate concern (assigned category 2B) for eye irritation.
Cat 3
Rationale
Modeled LC50 values for vertebrates and algae between 10-100 ppm are assigned acute category 3.
NC
Rationale
ECOSAR modeling estimations indicate chronic aquatic toxicity values <10 ppm. Given the low persistence for 3-methoxybutyl acetate, these predictions indicate low concern for chronic aquatic exposure because the aquatic toxicity data is accompanied by greater than 60% aerobic biodegradation within 10 days.
NC
Rationale
Chemical is not on Montreal Protocol or IPCC list
Other
  • Explosives: Not classified
  • Flammable Gases: Not classified
  • Aerosols: Not classified
  • Oxidizing Gases: Not classified
  • Flammable Liquids: Not classified
  • Flammable Solids: Not classified
  • Self-reactive substances and mixtures: Not classified
  • Pyrophoric Liquids: Not classified
  • Pyrophoric Solids: Not classified
  • Self-heating Substances and Mixtures: Not classified
  • Substances and Mixtures which in contact with water, emit flammable gases: Not classified
  • Oxidizing Liquids: Not classified
  • Oxidizing Solids: Not classified
  • Organic Peroxides: Not classified
  • Corrosive to Metals: Not classified
  • Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health
Environmental
Other
 
Carcinogenicity
Mutagenicity
Reproductive & Developmental Toxicity
Endocrine Activity / Disruption
Oral Toxicity
Dermal Toxicity
Inhalation Toxicity
Neurotoxicity
Skin, Eye, and Respiratory Corrosion/Irritation
Sensitization of Skin and Airways
Fish Toxicity
Daphnia Toxicity
Algae Toxicity
Terrestrial Toxicity
Persistence
Bioaccumulation
Climatic Relevance
Other (Human Health)
Organohalogens
Toxic Metals
Other (Environmental Health)
Oral
Dermal
Inhalation
-
-
-
G
G
-
-
-
Rationale
No data available.
G
-
-
G
-
-
Y
G
Y
G
Y
-
G
Rationale
Given the low hazard results for mammalian toxicity, and evidence of aerobic biodegradation, EPA has sufficient information to anticipate low concern for this chemical if present in anaerobic environments.
G
Rationale
Based on the estimated BAF value of 7.7, using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that 3-methoxybutyl acetate has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.
Y
G
Rationale
No data available.
G
G
G
Rationale
No data available.