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Propanol, [(1-methyl-1,2-ethanediyl)bis(oxy)]bis-

CASRN#

24800-44-0

INCI Name

TRIPROPYLENE GLYCOL

Alternate Names

Tripropylene Glycol; Propanol, [(1-methyl-1,2-ethanediyl)bis(oxy)]bis-; ((Methylethylene)bis(oxy))dipropanol; 2-(2-(2-Hydroxypropoxy)propoxy)-1-propanol; 2-(2-(2-Hydroxypropoxy)propoxy)propan1-ol; Tripropylene glycolmixture of isomers; 1-Propanol, 2-(2-(2

Common Trade Names

TPG

Molecular Weight

192 g/mol

Functional Uses

Solvent

Common Impurities

Is this a VOC?

Is this an exempt VOC?

Vapor Pressure

0.0023 mm Hg

Octanol-water partition coefficient (log Kow)

-0.379

Solubility at 2E+1 C

1E+6 mg/l

Boiling Point

271 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

GHS Health

None

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 9, 2025

Verification Status

verified

Executive Summary

Tripropylene glycol is a mixture of isomeric chemical compounds formed as a byproduct or coproduct of the manufacture of propylene glycol. Tripropylene glycol is a colorless, nearly odorless, and slightly viscous liquid with a high boiling point. It is hygroscopic, completely soluble in water, and can also dissolve oils. These properties make tripropylene glycol a highly functional solvent used in a variety of applications and product sectors. NOTE: The data provided in this assessment came primarily from the US EPA final designation report, Supporting Information for Low-Priority Substance Propanol, [(1-methyl-1,2-ethanediyl)bis(oxy)]bis- (tripropylene glycol) (https://www.regulations.gov/document?D=EPA-HQ-OPPT-2019-0122-0012). According to US EPA, “low-priority substance designations give the public notice of chemical substances for which the hazard and/or exposure potential is anticipated to be low or nonexistent and provides some insight into which chemical substances are likely not to need additional evaluation and risk management under TSCA.”

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Lower confidence due to analog data. Analog data indicate carcinogenicity from oral exposures is unlikely. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Lower confidence due to use of analog data. Negative results for an analog indicate low concern for mutagenicity.	NC Rationale No adverse effects observed in a one-generation reproductive study indicate low concern for reproductive toxicity. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Several studies indicate low concern for acute toxicity from oral exposures. NC Rationale A study indicates low concern for acute toxicity from dermal exposures. NC Rationale Based on the chemical’s physical-chemical properties and available experimental data, these results provide sufficient information to indicate low concern for acute toxicity from inhalation exposures based on no adverse effects reported at expected air saturation.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale Data not available.	NC Rationale Lower confidence due to weight of evidence using data from tripropylene glycol reproductive study and an analog which provide sufficient information to indicate low concr for toxicity resulting from repeated oral exposure. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale While no traditional neurotoxicity studies were available for tripropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for tripropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for tripropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity.	NC Rationale While no traditional neurotoxicity studies were available for dipropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for tripropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for tripropylene glycol or closely-related analogs, the available data provide sufficient evidence to indicate a low concern for neurotoxicity.	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale These results provide sufficient information to indicate a low concern for skin irritation by tripropylene glycol.	NC Rationale These results provide sufficient information to indicate a low concern for eye irritation by tripropylene glycol.	NC Rationale Studies on algae indicate low concern for acute exposure.	NC Rationale ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.	NC Rationale Chemical is not on Montreal Protocol or IPCC list.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	G - -	G	G - -	- Rationale No data available.	G	G	G	G G G	G	G	G	G	G	-	G Rationale Varied results are observed in the experimental ready test data . The weight of evidence of the available biodegradation results meet the low-concern benchmark and provide sufficient information to indicate low concern for persistence.	G Rationale Based on the estimated bioaccumulation factor (BAF) value of 0.9 using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information to indicate tripropylene glycol has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.	G	G Rationale No additional data available.	G	G	G Rationale No additional data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

Propanol, [(1-methyl-1,2-ethanediyl)bis(oxy)]bis-

Hazard Summary

Hazard Tables

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C2C Chemical Ratings

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How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table