ChemForward Alternatives

Propanol, 1(or 2)- (2-methoxymethylethoxy)-, acetate

CASRN#

88917-22-0

INCI Name

PPG-2 METHYL ETHER ACETATE

Alternate Names

DPMA, 1-(3-Methoxypropoxy)propyl acetate, Glycol Ether DPM Acetate, 1(or2)-(2methoxymethylethoxy)-propanoacetate, propanol,1(or2)-(2-methoxymethylethoxy)-,acetate, PPG-2 Methyl Ether Acetate

Common Trade Names

DPMAc, Dowanol DPMA

Molecular Weight

1.9E+2 g/mol

Functional Uses

Solvent, fragrance, film-forming agent, coalescing agent

Common Impurities

Is this a VOC?

Yes

Is this an exempt VOC?

Vapor Pressure

0.13 mm Hg

Octanol-water partition coefficient (log Kow)

0.803

Solubility at 25 C

1.94E+5 mg/l

Boiling Point

209 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

GHS Health

None

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Apr 20, 2020

Assessment Expires

Apr 20, 2025

Verification Status

verified

Executive Summary

DPMA is a propylene oxide-based, or P-series, glycol ether acetate. DPMA is an organic chemical compound that contains an ester functional group comprised of two alkyl groups connected by a carbonyl and a linking oxygen atom (RCOOR’) and two ether functional groups--an oxygen atom connected two alkyl groups (R-O-R’). DPMA is commercially produced as a mixture of four isomeric components in which the internal ether linkage may be adjacent to either a primary or secondary carbon atom. Shorter chain ethers and esters, such as DPMA, are liquids capable of dissolving other substances and typically function as solvents. DPMA is a colorless, water-soluble, sweet-smelling liquid with a moderate evaporation rate, and it is miscible with organic solvents. These properties make DPMA useful as a solvent, fragrance, film-forming agent, and coalescing agent in a variety of applications and product sectors. Section 5 includes conditions of use for this chemical.

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data. NC Rationale Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data. NC Rationale Available data is insufficient for GHS classification: DPMA’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. Lower confidence due to modeled data.	NC Rationale Weight of evidence indicates low concern for inducing genotoxicity.	NC Rationale Lower confidence due to analog data. Analog data indicate low concern for reproductive toxicity. CNP Rationale No data available. CNP Rationale No data available.	CNP Rationale Data not available. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity.	NC Rationale Multiple studies indicating low-concern of acute toxicity. NC Rationale Multiple studies indicating low-concern of acute toxicity. NC Rationale Findings in one study indicating low-concern of acute toxicity.	CNP Rationale No data available. NC Rationale No adverse effects at high dose exposure after a single dose. NC Rationale No data available.	NC Rationale Study findings indicating low-concern of toxicity from repeated exposure. NC Rationale Weight of evidence across multiple studies suggest findings indicate low concern for repeated dermal exposure. NC Rationale Findings in one study indicating low-concern after repeat dosing.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale No guideline neurotoxicity studies on DPMA or closely-related analogs were available to assess the potential for DPMA to cause neurotoxicity. DPMA’s low-concern findings for other human health hazard endpoints, including toxicity from acute and repeated exposures, and predictions by ToxCast, provide sufficient information to indicate low concern for neurotoxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale Multiple studies indicate low concern for skin irritation.	NC Rationale Multiple studies indicate low concern for eye irritation.	NC Rationale Aquatic toxicity results provide sufficient information to indicate low concern for acute aquatic exposure by exceeding the low-concern benchmark of 10 mg/L.	NC Rationale ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.	NC Rationale Chemical is not listed as an ozone depletor according to the Montreal Protocol or a greenhouse gas according to IPCC report.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Category 4
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified
Lactation Toxicity: Classification not possible (Data gap or insufficient data)
Aspiration: Classification not possible (Data gap or insufficient data)

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	- - -	G	G G G	- Rationale No data available.	G	G	G	G - -	G	G	G	G	G	-	Y Rationale No degradation products of concern were identified for this chemical substance. Based on the reasonably available information and weight of the scientific evidence, sufficient information indicates that this chemical will have low persistence.	G Rationale Based on the estimated bioaccumulation factor (BAF) value of 1.1, using Estimation Programs Interface (EPI) Suite models, indicates a low potential for bioaccumulation in the environment based on the low-concern threshold of less than 1000.	Y	G Rationale No data available	G	G	G Rationale No data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

Propanol, 1(or 2)- (2-methoxymethylethoxy)-, acetate

Hazard Summary

Hazard Tables

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Human Health

Environmental

Other

Rationale

Rationale

Rationale

Rationale

Rationale

C2C Chemical Ratings

GHS

Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table