ChemForward Alternatives

2-Propanol, 1,1'-oxybis-

CASRN#

110-98-5

INCI Name

DIPROPYLENE GLYCOL

Alternate Names

1,1'-OXYDI-2-PROPANOL, 2-Propanol, 1,1'-oxybis-, 1,1'-Oxydipropan-2-ol, 1,1'-Oxybis-2-propanol, Bis(2-hydroxypropyl) ether

Common Trade Names

NIAX Catalyst D-19

Molecular Weight

134.18 g/mol

Functional Uses

Solvent, humectant, plasticizer

Common Impurities

Is this a VOC?

Yes

Is this an exempt VOC?

Vapor Pressure

0.03 mm Hg

Octanol-water partition coefficient (log Kow)

-0.64

Solubility at 25 C

1E+6 mg/l

Boiling Point

233 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

c/b

GHS Health

None

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 9, 2025

Verification Status

verified

Executive Summary

1,1'-Dimethyldiethylene glycol is a P-series glycol ether, meaning that it is made from propylene oxide. Glycol ethers are organic chemical compounds that contain both an alcohol functional group (R-OH) and an ether functional group, which is an oxygen atom connected to two alkyl groups (R-O-R’). 1,1'- Dimethyldiethylene glycol is an isomer of dipropylene glycol with two iso-propyl groups on either side of the ether group. 1,1'-Dimethyldiethylene glycol is produced as a byproduct of the manufacture of propylene glycol. 1,1'-Dimethyldiethylene glycol is an odorless solvent with a high boiling point and is completely soluble in water while also maintaining the ability to dissolve oils. In addition, 1,1'- dimethyldiethylene glycol is hygroscopic and acts as a humectant, which means it absorbs water and increases hydration in products. 1,1'-Dimethyldiethylene glycol also functions as a plasticizer and as a plasticizer intermediate in the formation of polyurethane polyols to give improved flexibility and resistance to cracking at low temperatures. A plasticizer is a substance that is added to a material to alter its physical properties, mainly to increase flexibility or decrease viscosity. These properties make 1,1'- dimethyldiethylene glycol a multifunctional ingredient used in a variety of applications and product sectors. Section 5 includes conditions of use for this chemical.

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Lower confidence due to analog data. Analog data indicate carcinogenicity from oral exposures is unlikely. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Lower confidence due to use of analog data. Negative results for an analog indicate low concern for mutagenicity.	NC Rationale Lower confidence due to analog data. Analog data indicate no adverse effects on mating, fertility, and estrus cycle, suggesting low concern for reproductive toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Two studies indicate low concern for acute toxicity from oral exposures.. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for acute toxicity from dermal exposures. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for acute toxicity from inhalation exposures based on no adverse effects reported at expected air saturation.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Lower confidence due to analog data. Several studies on analogs indicate low concern for repeated dose toxicity from oral exposures. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Relevant endpoints in rats acutely exposed to dipropylene glycol by oral gavage noted decreased motor activity and ataxia for a few hours after exposure to the high dose of 5010 mg/kg. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Relevant endpoints measured in analog repeated dose studies and in vitro high throughout biochemical-and cell-based assays related to neurological functions for 1,1’dimethyldiethylene glycol indicate low concern for neurotoxicity. Lower confidence due to use of analog data and not traditional neurotoxicity studies. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Negative analog results in experimental studies indicate low concern for skin sensitization for 1,1’dimethyldiethylene glycol.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale Lower confidence due to analog data. Analog data indicates low concern for skin irritation.	NC Rationale Lower confidence due to analog data. Analog data indicates low concern for eye irritation.	NC Rationale Lower confidence due to analog data. Analog data on aquatic vertebrates, invertebrates, and algae indicate low concern for acute exposure.	NC Rationale ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.	NC Rationale Chemical is not on Montreal Protocol or IPCC list.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	G - -	G	G - -	- Rationale No data available.	G	G	G	G - -	G	G	G	G	G	-	G Rationale Varied results are observed in the experimental ready test data . The weight of evidence of the available biodegradation results meet the low-concern benchmark and provide sufficient information to indicate low concern for persistence.	G Rationale Based on the estimated bioaccumulation factor (BAF) value of 0.9 using the Estimation Programs Interface (EPI) Suite models, 1,1’-dimethyldiethylene glycol is expected to have low potential for bioaccumulation in the environment based on the low concern threshold of less than 1000.	Y	G Rationale No data available.	G	G	G Rationale No data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

2-Propanol, 1,1'-oxybis-

Hazard Summary

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C2C Chemical Ratings

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Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table