The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around the world. It aims at ensuring that information on physical hazards and toxicity from chemicals be available in order to enhance the protection of human health and the environment during the handling, transport and use of these chemicals. The GHS also provides a basis for harmonization of rules and regulations on chemicals at national, regional and worldwide level, an important factor also for trade facilitation. Core elements of the GHS include standardized hazard testing criteria, universal warning pictograms, and harmonized safety data sheets which provide users of dangerous goods with a host of information. GHS endpoints are grouped into physical hazards, health hazards and environmental hazards. We present summary information for classification results. Hazard statement codes are presented separately for health hazards and environmental hazards. Detail for each endpoint and physical hazards can be found in the hazard summary table view.

The ChemForward Verification Program ensures the quality and consistency of chemical hazard assessments by providing an additional layer of quality control by an independent toxicology expert. Verified CHAs are:

• Complete. According the ChemForward GHS-based input method and guidance;
• Current. Updated regularly according to ChemForward program requirements (currently every three years);
• Based on data that are as relevant, reliable and adequate as feasible;
• Accurate in applying classification or rating criteria to existing data;
• Transparent and appropriate in applying expert judgment in the evaluation of existing data, especially when various data streams differ; and
• Transparent and appropriate in supplementing test data with New Approach Methods (NAMs) for filling data gaps for hazard classification needs.

The GHS hazard summary tables generated for this chemical are based on a full chemical hazard assessment (CHA) performed by a qualified ChemFORWARD Assessor and verified by an independent expert toxicologist. Data sources include authoritative governmental databases (e.g. ECHA, US EPA), international toxicological literature, and New Approach Methods including read across and predictive toxicology tools such as QSAR as needed to fill data gaps.

The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around the world. It aims at ensuring that information on physical hazards and toxicity from chemicals be available in order to enhance the protection of human health and the environment during the handling, transport and use of these chemicals.

All classifications are based on the Globally Harmonised System of Classification and Labeling of Hazards (GHS) Rev 8.

• Cat = Category (1, 1A, 1B, 2, 3, etc.)
• NC = Not classified (equivalent to low hazard using GHS criteria)
• CNP = Classification Not Possible (no data available)

Color coding:

• Red: Category is accompanied by GHS Signal Word ‘Danger’
• Orange: Category is accompanied by GHS Signal Word ‘Warning’
• Yellow: Category is accompanied by no GHS Signal Word
• Green: Not Classified

Confidence indicators:

• Bold text: High confidence
• (Italic text in parentheses): Low confidence
• Plain text: Classification not possible

The C2CC hazard summary tables generated for this chemical are based on a full chemical hazard assessment (CHA) performed by a qualified ChemFORWARD Assessor and verified by an independent expert toxicologist. Data sources include authoritative governmental databases (e.g. ECHA, US EPA), international toxicological literature, and New Approach Methods including read across and predictive toxicology tools such as QSAR as needed to fill data gaps.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption.

All classifications are based on most recent version of the Cradle to Cradle Material Health Methodology (Feb 2022). The Cradle to Cradle endpoint hazard rating uses color to indicate the following:

• Green: No hazard identified for the endpoint
• Yellow: Borderline hazard identified for the endpoint
• Red: Considered hazardous for the endpoint
• Purple: Considered hazardous for the endpoint (applies to persistence and bioaccumulation potential only)
• Grey: Insufficient data available to determine hards level for the endpoint