ChemForward Alternatives

Propanol, [2-(2-butoxymethylethoxy)methylethoxy]-

CASRN#

55934-93-5

INCI Name

PPG-3 BUTYL ETHER

Alternate Names

Tripropylene glycol butyl ether

Common Trade Names

DOWANOL TPnB Glycol Ether; TPnB

Molecular Weight

248.4 g/mol

Functional Uses

Solvent, coalescing agent, film-forming agent

Common Impurities

Is this a VOC?

Is this an exempt VOC?

Vapor Pressure

0.00308 mm Hg

Octanol-water partition coefficient (log Kow)

1.9

Solubility at 25 C

4.02E+4 mg/l

Boiling Point

274 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

c/b

GHS Health

H316H320

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 10, 2025

Verification Status

verified

Executive Summary

Tripropylene glycol n-butyl ether (TPnB) is a P-series glycol ether, meaning that it is made from propylene oxide. Glycol ethers are organic chemical compounds that contain both an alcohol functional group (R-OH) and an ether functional group, which is an oxygen atom connected to two alkyl groups (RO-R’). TPnB is a linear molecule that can be composed of three isomeric propylene oxide groups linked together through ether groups, terminating in a n-butyl carbon chain on one end and an alcohol on the other. Shorter chain ethers and esters, such as TPnB, are liquids capable of dissolving other substances and typically function as solvents. TPnB is a colorless to light yellow hydrophobic liquid with a high boiling point and low volatility. These properties make TPnB a useful solvent, coalescing agent, and filmforming agent in a variety of applications and product sectors.

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: Tripropylene glycol n-butyl ether’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.	NC Rationale Weighing the negative results in several cell lines with the positive results occurring only at cytotoxic concentrations, EPA interprets these results to indicate DPMA has low concern for inducing genotoxicity.	NC Rationale No adverse effects observed in a one-generation reproductive study indicate low concern for reproductive toxicity. CNP Rationale Data not available. CNP Rationale Data not available.	CNP Rationale Data not available. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for developmental toxicity from dermal exposures. NC Rationale Several studies indicate low concern for developmental toxicity from vapor and aerosol exposures to tripropylene glycol n-butyl ether.	NC Rationale Several studies indicate low concern for acute toxicity from oral exposures. NC Rationale An OECD Guideline 402 study indicates low concern for acute toxicity from dermal exposures. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for acute toxicity from inhalation exposures.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Several studies indicate low concern for repeated dose toxicity from oral exposures. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for repeated dose toxicity from dermal exposures. NC Rationale Lower confidence due to analog data. Analog data indicate low concern for repeated dose toxicity from inhalation exposures.	CNP Rationale Data not available. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Relevant endpoints measured in a repeated dose study and in vitro high throughout biochemical-and cell-based assays related to neurological functions indicate low concern for neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available. NC Rationale In vitro high throughout biochemical-and cell-based assays related to neurological functions to indicate low concern for neurotoxicity. Lower confidence due to use of new approach methodologies (NAMs). NC Rationale In vitro high throughout biochemical-and cell-based assays related to neurological functions indicate low concern for neurotoxicity. Lower confidence due to use of new approach methodologies (NAMs).	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification. The weight of scientific evidence provides sufficient information to indicate low concern for respiratory sensitization.	Cat 3 Rationale Lower confidence due to analog data. Analog data indicates low severity and reversibility (assigned category 3) for skin irritation.	Cat 2B Rationale Mixed results indicate moderate concern (assigned category 2B) for eye irritation.	NC Rationale Studies on aquatic vertebrates, invertebrates, and algae indicate low concern for acute exposure.	NC Rationale ECOSAR modeling estimations indicate chronic aquatic toxicity values >10 ppm. Lower confidence due to use of modeling.	NC Rationale Chemical is not on Montreal Protocol or IPCC list.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified
Lactation Toxicity: Classification not possible (Data gap or insufficient data)
Aspiration: Classification not possible (Data gap or insufficient data)

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	- - -	G	G G G	- Rationale No data available.	G	G	G	G - -	Y	G	G	G	G	-	G Rationale The available biodegradation results meet the low-concern threshold and indicate this chemical will have low persistence.	G Rationale Based on the estimated BAF value of 6.22, using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that tripropylene glycol n-butyl ether has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.	G	G Rationale No data available.	G	G	G Rationale No data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

Propanol, [2-(2-butoxymethylethoxy)methylethoxy]-

Hazard Summary

Hazard Tables

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Rationale

Human Health

Environmental

Other

Rationale

Rationale

Rationale

Rationale

Rationale

C2C Chemical Ratings

GHS

Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table