ChemForward Alternatives

1-Butanol, 3-methoxy-, 1-acetate

CASRN#

4435-53-4

INCI Name

Alternate Names

3-METHOXYBUTYL ACETATE, Butoxyl, Acetic Acid 3-Methoxybutyl Ester, 1-Butanol, 3-methoxy-, acetate, Acetic acid, 3-methoxybutyl ester

Common Trade Names

Butoxyl

Molecular Weight

146.19 g/mol

Functional Uses

Solvent

Common Impurities

Is this a VOC?

Yes

Is this an exempt VOC?

Vapor Pressure

0.44 mm Hg

Octanol-water partition coefficient (log Kow)

1.01

Solubility at 25 C

4.6E+3 mg/l

Boiling Point

135 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

grey/c

GHS Health

H320

GHS Enviro

H402

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 10, 2025

Verification Status

verified

Executive Summary

3-Methoxybutyl acetate is an organic chemical compound that contains both an ester functional group, which is a pair of alkyl groups connecting by a carbonyl and a linking oxygen atom (RCOOR), and an ether functional group, which is an oxygen atom connected two alkyl groups (R-O-R). Shorter chain ethers and esters typically function as solvents, which are liquids capable of dissolving other substances. 3-Methoxybutyl acetate is water soluble and miscible with common organic solvents. These properties make 3-methoxybutyl acetate ideal for use as a solvent in a variety of applications and product sectors.

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: 3-methoxybutyl acetate’s transformation profile, lack of structural alerts in the parent chemical substance, and negative genotoxicity results indicate this chemical is unlikely to be carcinogenic.	NC Rationale Negative results for mutagenicity tests indicate low concern for genotoxicity.	NC Rationale Lower confidence due to combined repeated dose toxicity study with reproduction toxicity screening. No reproductive effects on mating, fertility, and estrus cycle indicate low concern for reproductive toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale No adverse effects observed in a prenatal development study indicate low concern for developmental toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Lower confidence due to weight of evidence using data from 3-methoxybutyl acetate and an analog to indicate low concern for acute toxicity. CNP Rationale No data available. CNP Rationale No data available.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale A 28-day repeated dose study indicated no adverse effects at the low-concern threshold. CNP Rationale No data available. CNP Rationale No data available.	CNP Rationale No data available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Relevant endpoints measured in a repeated dose study to indicate low concern for neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. The results from these NAMs and weight of the scientific evidence provide sufficient information to indicate low concern for respiratory sensitization.	NC Rationale Lower confidence due to analog data. Analog data indicates low concern for skin irritation.	Cat 2B Rationale Effects that were fully reversible within 48-hours indicate moderate concern (assigned category 2B) for eye irritation.	Cat 3 Rationale Modeled LC50 values for vertebrates and algae between 10-100 ppm are assigned acute category 3.	NC Rationale ECOSAR modeling estimations indicate chronic aquatic toxicity values <10 ppm. Given the low persistence for 3-methoxybutyl acetate, these predictions indicate low concern for chronic aquatic exposure because the aquatic toxicity data is accompanied by greater than 60% aerobic biodegradation within 10 days.	NC Rationale Chemical is not on Montreal Protocol or IPCC list

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified
Lactation Toxicity: Classification not possible (Data gap or insufficient data)
Aspiration: Classification not possible (Data gap or insufficient data)

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	- - -	G	G - -	- Rationale No data available.	G	-	-	G - -	Y	G	Y	G	Y	-	G Rationale Given the low hazard results for mammalian toxicity, and evidence of aerobic biodegradation, EPA has sufficient information to anticipate low concern for this chemical if present in anaerobic environments.	G Rationale Based on the estimated BAF value of 7.7, using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that 3-methoxybutyl acetate has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.	Y	G Rationale No data available.	G	G	G Rationale No data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

1-Butanol, 3-methoxy-, 1-acetate

Hazard Summary

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C2C Chemical Ratings

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Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table