ChemForward Alternatives

D-gluco-Heptonic acid, sodium salt (1:1), (2xi)-

CASRN#

31138-65-5, 2670-72-6

INCI Name

SODIUM GLUCEPTATE

Alternate Names

alpha-D-Glucoheptonic acid sodium salt; D-Gluco-heptonic acid, monosodium salt; D-glycero-D-guloHeptonic acid sodium salt; D-glycero-D-gulo-Heptonic acid, monosodium salt; Gluceptate Sodium; Glucoheptonic Acid Sodium Salt; Glucosecarboxylic Acid Sodium Sa

Common Trade Names

SEQLENE 540; SEQLENE ES-50; H-Quest L-50 LA; Milco 150

Molecular Weight

248 g/mol

Functional Uses

chelating agent

Common Impurities

Is this a VOC?

Is this an exempt VOC?

Vapor Pressure

1.2E-19 mm Hg

Octanol-water partition coefficient (log Kow)

-6.44

Solubility at 25 C

1E+6 mg/l

Boiling Point

117 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

c/b

GHS Health

H320

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 10, 2025

Verification Status

verified

Executive Summary

Sodium glucoheptonate belongs to the hydroxycarboxylic acid salt family. The chemical structure of sodium glucoheptonate consists of a seven-carbon chain with hydroxyl (-OH) groups terminating in a carboxylic acid group. The close proximity of the oxygen atoms within the chemical structure lends to its function as a highly efficient chelating agent, by binding to positively charged metal ions in solution and thereby prevent these ions from forming insoluble precipitates with other ions that may be present. Sodium glucoheptonate functions as a chelating agent over a wide pH range due to its efficiency in forming stable chelates with divalent and trivalent metal ions such as calcium, magnesium, iron, aluminum, and other metals, thereby reducing the adverse effects these metals can have on systems. These properties contribute to the use of sodium glucoheptonate as a high performing chelating agent in a variety of applications and product sectors. NOTE: The data provided in this assessment came primarily from the US EPA final designation report, Supporting Information for Low-Priority Substance D-gluco-Heptonic acid, sodium salt (1:1), (2.xi.)- (Sodium Glucoheptonate) (https://www.regulations.gov/document?D=EPA-HQ-OPPT-2019-0107-0010). According to US EPA, “low-priority substance designations give the public notice of chemical substances for which the hazard and/or exposure potential is anticipated to be low or nonexistent and provides some insight into which chemical substances are likely not to need additional evaluation and risk management under TSCA.”

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Available data is insufficient for GHS classification: sodium glucoheptonate’s transformation profile, lack of structural alerts in the parent chemical substance, modelled predictions of non-carcinogenicity, and experimental genotoxicity results provide sufficient information to indicate that this chemical has low concern for carcinogenicity. NC Rationale Available data is insufficient for GHS classification: sodium glucoheptonate’s transformation profile, lack of structural alerts in the parent chemical substance, modelled predictions of non-carcinogenicity, and experimental genotoxicity results provide sufficient information to indicate that this chemical has low concern for carcinogenicity. NC Rationale Available data is insufficient for GHS classification: sodium glucoheptonate’s transformation profile, lack of structural alerts in the parent chemical substance, modelled predictions of non-carcinogenicity, and experimental genotoxicity results provide sufficient information to indicate that this chemical has low concern for carcinogenicity.	NC Rationale Multiple studies provide sufficient evidence to indicate low concern for genotoxicity.	NC Rationale Lower confidence due to use of combined repeat dose, reproductive, developmental toxicity study. No reproductive effects were observed in an OECD 422 study which provides sufficient evidence to indicate low concern for reproductive toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale Lower confidence due to use of combined repeat dose, reproductive, developmental toxicity study. No reproductive effects were observed in an OECD 422 study, and multiple analog studies, which provide sufficient evidence to indicate low concern for developmental toxicity. CNP Rationale No data available. CNP Rationale No data available.	NC Rationale This study provides sufficient evidence to indicate a low concern for acute oral toxicity. NC Rationale This study provides sufficient evidence to indicate a low concern for acute dermal toxicity. CNP Rationale Data not available.	CNP Rationale Data not available. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale This study provides sufficient evidence to indicate a low concern for repeat dose oral toxicity. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Relevant endpoints measured in a OECD 422 repeat dose toxicity study provide sufficient information to indicate a low concern of neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Relevant endpoints measured in a OECD 422 repeat dose toxicity study provide sufficient information to indicate a low concern of neurotoxicity. Lower confidence due to no traditional neurotoxicity studies available. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale An OECD Guideline 429 study provides sufficient information to indicate low concern for skin sensitization.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale Multiple studies provide sufficient evidence to indicate low concer for skin irritation. Lower confidence due to analog.	Cat 2B Rationale Multiple studies on analogs provides sufficient evidence to indicate moderate concern for eye irritation. Lower confidence due to analog.	NC Rationale Studies on aquatic vertebrates provides sufficient information to indicate low concern for acute exposure.	NC Rationale Predicted toxicity values from modelling provide sufficient evidence to indicate a low concern for chronic exposure to algae.	NC Rationale Chemical is not on Montreal Protocol or IPCC List.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified
Lactation Toxicity: Classification not possible (Data gap or insufficient data)
Aspiration: Classification not possible (Data gap or insufficient data)

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	- - -	G	G - -	- Rationale No data available.	G	G	-	G - -	Y	G	G	G	G	-	G Rationale Available biodegradation studies provide sufficient evidence of low concern for persistence.	G Rationale Based on the estimated bioaccumulation factor (BAF) value of 3.16 using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that sodium glucoheptonate has low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.	Y	G Rationale No additional data available.	G	G	G Rationale No additional data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

D-gluco-Heptonic acid, sodium salt (1:1), (2xi)-

Hazard Summary

Hazard Tables

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C2C Chemical Ratings

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Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table