ChemForward Alternatives

1-Eicosanol

CASRN#

629-96-9, 28679-05-2, 90604-34-5

INCI Name

ARACHIDYL ALCOHOL

Alternate Names

Icosan-1-ol; Arachidyl alcohol; N-Eicosanol; Arachidic a 1-ol; Eicosanol; 1-Icosanol; N-1-Eicosanol lcohol; Eicosyl alcohol; eicosan

Common Trade Names

Alfol 20+ Alcohol

Molecular Weight

298.55 g/mol

Functional Uses

thickener, emulsifier, emollient, opacifier

Common Impurities

Is this a VOC?

Is this an exempt VOC?

Vapor Pressure

1.13E-7 mm Hg

Octanol-water partition coefficient (log Kow)

8.3

Solubility at 25 C

0.000843 mg/l

Boiling Point

372 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

c/b

GHS Health

H320

GHS Enviro

None

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 9, 2025

Verification Status

verified

Executive Summary

1-Eicosanol is a long-chain, saturated fatty alcohol that is a water-insoluble, waxy solid. Fatty alcohols are usually high-molecular-weight, straight-chain primary alcohols derived from natural fats and oils. Saturated fatty alcohols have no carbon-carbon double bonds, and they have the formula – CH3(CH2)nOH – with variations in “n.” Specifically, 1-eicosanol is a saturated aliphatic alcohol with a 20-carbon chain, known as eicosane, with a hydroxy group (-OH) at the terminal carbon and the formula CH3(CH2)19OH. 1-eicosanol functions as a thickener, emulsifier, and emollient. NOTE: The data provided in this assessment came primarily from the US EPA final designation report, Supporting Information for Low-Priority Substance 1-Eicosanol (Arachidyl Alcohol) (https://www.regulations.gov/document?D=EPA-HQ-OPPT-2019-0115-0009). According to US EPA, “low-priority substance designations give the public notice of chemical substances for which the hazard and/or exposure potential is anticipated to be low or nonexistent and provides some insight into which chemical substances are likely not to need additional evaluation and risk management under TSCA.”

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale Available data is insufficient for GHS classification: 1-eicosanol's transformation profile, lack of structural alerts, noncarcinogenic predictions, and negative genotoxicity results provide sufficient information to indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: 1-eicosanol's transformation profile, lack of structural alerts, noncarcinogenic predictions, and negative genotoxicity results provide sufficient information to indicate this chemical is unlikely to be carcinogenic. NC Rationale Available data is insufficient for GHS classification: 1-eicosanol's transformation profile, lack of structural alerts, noncarcinogenic predictions, and negative genotoxicity results provide sufficient information to indicate this chemical is unlikely to be carcinogenic.	NC Rationale Multiple studies from analogs provide sufficient information to indicate a low concern for genotoxicity. Lower confidence due to analogs.	NC Rationale Multiple studies provide sufficient evidence to indicate a low concern for reproductive toxicity. Lower confidence due to analogs. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Multiple studies provide sufficient evidence to indicate a low concern for developmental toxicity. Lower confidence due to analogs. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Multiple studies provide sufficient evidenc to indicate low concern for acute oral toxicity. NC Rationale Studies from analogs provide sufficient evidence to indicate a low concern for acute dermal toxicity. Lower confidence due to analogs. NC Rationale Studies from analogs provide sufficient information to indicate a low concern for acute inhalation toxicity since no adverse effects were seen at saturated air concentration.	CNP Rationale Data not available. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Studies from analogs provide sufficient evidence to indicate a low concern for repeat dose oral toxicity. Lower confidence due to analogs. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Based on the neurological evidence from the repeated dose studies in analogs, and supporting evidence indicating low concern for other endpoints, such as acute, reproductive, and developmental toxicity, provides sufficient information to indicate low concern for neurotoxicity. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Based on the neurological evidence from the repeated dose studies in analogs, and supporting evidence indicating low concern for other endpoints, such as acute, reproductive, and developmental toxicity, provides sufficient information to indicate low concern for neurotoxicity. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale Multiple studies from analogs provide sufficient information to indicate a low concern for skin irritation.	Cat 2B Rationale Multiple studies from analogs provide ssufficient evidence to indicate moderate concern for eye irritation.	NC Rationale Modelling and multiple studies on analogs provide sufficient evidence to indicate low concer for acute aquatic exposure based on no effects at saturation.	NC Rationale Modelling and studies for analogs on aquatic invertebrates provide sufficient evidence to indicate low concer for chronic aquatic exposure based on no effects at saturation.	NC Rationale Chemical is not on Montreal Protocol or IPCC List.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	- - -	G	G - -	- Rationale Data not available.	G	G	G	G - -	Y	G	G	G	G	-	G Rationale Multiple studies provide sufficient information to indicate low concern for persistence. Lower confidence due to analogs.	G Rationale Studies on analogs provide sufficient information to indicate low concern for bioaccumulation.	G	G Rationale No additional data available.	G	G	G Rationale No additional data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

1-Eicosanol

Hazard Summary

Hazard Tables

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C2C Chemical Ratings

GHS

Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table