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DIBUTYL SEBACATE

CASRN#

109-43-3

INCI Name

DIBUTYL SEBACATE

Alternate Names

Dibutyl decanedioate; Butyl sebacate; Di-n-butyl sebacate, Decanedioic acid dibutyl ester, Bis(n-butyl) sebacate, Di-n-butylsebacate, Sebacic acid dibutyl ester, Bis(n-butyl)sebacate; Decanedioic acid, 1,10-dibutyl ester

Common Trade Names

Polycizer DBS, Kodaflex DBS, Staflex DBS, Monoplex DBS

Molecular Weight

314 g/mol

Functional Uses

Solvent; plasticizer

Common Impurities

Is this a VOC?

Is this an exempt VOC?

Vapor Pressure

0.00000469 mm Hg

Octanol-water partition coefficient (log Kow)

6.3

Solubility at 2E+1 C

4E+1 mg/l

Boiling Point

344.5 °C

Particle size range as aerodynamic diameter

- - - μm

Hazard Summary

C2C Chemical Rating

grey/c

GHS Health

H320

GHS Enviro

H411

Assessed by

U.S. EPA Low Priority Chemical report.

Assessment Date

Jul 10, 2020

Assessment Expires

Jul 10, 2025

Verification Status

verified

Executive Summary

Dibutyl sebacate is an ester of sebacic acid -a saturated, straight-10-carbon-chain, naturally occurring dicarboxylic acid that is derived from castor oil. An ester is an organic chemical compound derived from an acid in which a hydroxyl (-OH) group is replaced by an alkoxy (-OR) group through the process of esterification. Shorter chain aliphatic diesters, such as dibutyl sebacate, function as plasticizers to give improved flexibility and resistance to cracking at low temperatures. A plasticizer is a substance that is added to a material to alter its physical properties, mainly to increase flexibility or decrease viscosity. These aliphatic diesters are also versatile solvents in that they are able to dissolve a wide range of organic compounds. NOTE: The data provided in this assessment came primarily from the US EPA final designation report, Supporting Information for Low-Priority Substance Decanedioic acid, 1,10-dibutyl ester (Dibutyl Sebacate) (https://www.regulations.gov/document?D=EPA-HQ-OPPT-2019-0113-0010). According to US EPA, “low-priority substance designations give the public notice of chemical substances for which the hazard and/or exposure potential is anticipated to be low or nonexistent and provides some insight into which chemical substances are likely not to need additional evaluation and risk management under TSCA.”

Hazard Tables

How to read the GHS Hazard Summary Table

	Carcinogenicity	Mutagenicity	Reproductive Toxicity	Developmental Toxicity	Acute Toxicity	STOT-Single	STOT-Repeated	STOT- Neurotoxicity-Single	STOT- Neurotoxicity-Repeated	Skin Sensitizer	Respiratory Sensitizer	Skin Corrosion/Irritation	Serious Eye Damage/Eye Irritation	Acute Aquatic Toxicity	Chronic Aquatic Toxicity	Ozone Depletion
Oral Dermal Inhalation	NC Rationale These results provide sufficient information to indicate low concern for carcinogenicity by dibutyl sebacate. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Chromosomal aberration assay on dibutyl sebacate and bacterial mutation studies on analogs provide sufficient information to indicate dibutyl sebacate has low concern for inducing genotoxicity. Lower confidence due to use of analogs.	NC Rationale Lower confidence due to analog study. One generation reproductive study provides sufficient information to indicate low concern for reproductive toxicity by exceeding the low-concern benchmarks of 250 mg/kg-day for oral exposures. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Lower confidence due to analog study. One generation reproductive study provides sufficient information to indicate low concern for developmental toxicity by exceeding the low-concern benchmarks of 250 mg/kg-day for oral exposures. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale Studies provide sufficient information to indicate low concern for mammalian toxicity from acute oral exposure to dibutyl sebacate. CNP Rationale Data not available. CNP Rationale Data not available.	CNP Rationale Data not available. CNP Rationale Data not available. CNP Rationale No data available.	NC Rationale Studies provide sufficient information to indicate low concern for mammalian toxicity from repeated oral exposure to dibutyl sebacate. CNP Rationale Data not available. CNP Rationale Data not available.	NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity.	NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity. NC Rationale While no traditional neurotoxicity studies were available for dibutyl sebacate or closely-related analogs, the available data from repeated dose exposure and NAMs provide sufficient evidence to indicate a low concern for neurotoxicity.	NC Rationale No structural alerts identified for skin sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale No structural alerts identified for respiratory sensitization. Lower confidence because a lack of structural alerts is insufficient for establishing a GHS classification.	NC Rationale Analog studies provide sufficient information to indicate that dibutyl sebacate has low concern for skin irritation.	Cat 2B Rationale A study in rabbits indicate moderate concern for eye irritation from dibutyl sebacate.	NC Rationale Results provide suffiient information to indicate dibutyl sebacate is a low concern for acute aquatic exposures. Lower confidence due to modelling.	Cat 2 Rationale Modelling indicates high concern for chronic aquatic toxicity, however studies that demonstrate ready biodegradation reduce that concern. Collectively, these data provide sufficient evidence dibutyl sebecate is a low concern for chronic aquatic toxicity to vertebrates. Lower confidence based on modelling.	NC Rationale Chemical is not on Montreal Protocol or IPCC list.

Other

Explosives: Not classified
Flammable Gases: Not classified
Aerosols: Not classified
Oxidizing Gases: Not classified
Flammable Liquids: Not classified
Flammable Solids: Not classified
Self-reactive substances and mixtures: Not classified
Pyrophoric Liquids: Not classified
Pyrophoric Solids: Not classified
Self-heating Substances and Mixtures: Not classified
Substances and Mixtures which in contact with water, emit flammable gases: Not classified
Oxidizing Liquids: Not classified
Oxidizing Solids: Not classified
Organic Peroxides: Not classified
Corrosive to Metals: Not classified
Desensitized Explosives: Not classified
Lactation Toxicity: Classification not possible (Data gap or insufficient data)
Aspiration: Classification not possible (Data gap or insufficient data)

How to read the C2CC Hazard Summary Table

Human Health											Environmental							Other
	Carcinogenicity	Mutagenicity	Reproductive & Developmental Toxicity	Endocrine Activity / Disruption	Oral Toxicity	Dermal Toxicity	Inhalation Toxicity	Neurotoxicity	Skin, Eye, and Respiratory Corrosion/Irritation	Sensitization of Skin and Airways	Fish Toxicity	Daphnia Toxicity	Algae Toxicity	Terrestrial Toxicity	Persistence	Bioaccumulation	Climatic Relevance	Other (Human Health)	Organohalogens	Toxic Metals	Other (Environmental Health)
Oral Dermal Inhalation	G - -	G	G - -	- Rationale Data not available.	G	-	-	G G G	Y	G	R	G	R	G	G Rationale Studies on analogs provide sufficient evidence of low concern for persistence. Lower confidence due to analog data.	G Rationale Based on the estimated bioaccumulation factor (BAF) value of 29 using the Estimation Programs Interface (EPI) Suite models, EPA has sufficient information that dibutyl sebacate is expected to have low potential for bioaccumulation in the environment based on the low-concern benchmark of less than 1000.	G	G Rationale No additional data available.	G	G	G Rationale No additional data available.

The Cradle to Cradle Material Health Assessment Methodology assigns hazard ratings to 24 individual human and environmental health endpoints. The system is largely based on GHS with the addition of endpoints including but not limited to Persistence, Bioaccumulation Potential and Endocrine Activity/Disruption. The possible C2C Chemical Ratings that can result from ChemForward’s simplified C2C chemical rating logic are:

C2C Chemical Rating	Color	Short Definition	Rules Summary
a	green	preferred in all applications	Chemical has no YELLOW or RED hazards or Cancer data gaps.
b	green	preferred in all applications	Chemical has no YELLOW hazards but lacks long-term cancer studies.
c/b	yellow/ green	acceptable in all applications	Chemical has one or more YELLOW risk flags before considering application. Applications where exposure is possible would result in a ‘c’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘b’ rating.
grey/c	grey/ yellow	insufficient information available	Chemical has one or more GREY risk flags before considering application. Applications where exposure is possible would result in a ‘grey’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
x/c	red/ yellow	may be acceptable or problematic depending on application	Chemical has one or more RED risk flags before considering application. Applications where exposure is possible would result in a ‘x’ rating. Applications where exposure is unlikely or expected to be negligible would result in a ‘c’ rating.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list, is climatically active, and/or is an organohalogen.
x-PBT	red	problematic in all applications	Chemical has a RED hazard for Persistence, Bioaccumulation, and another endpoint.
N/A	red	problematic in all applications	Chemical is a toxic metal, all of which have a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	red	problematic in all applications	Chemical is on a regulatory concern list and has a RED hazard for Cancer, Mutagenicity, or Reproductive toxicity.
N/A	purple	banned in all applications	Chemical is on the C2C Certified banned list.

DIBUTYL SEBACATE

Hazard Summary

Hazard Tables

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C2C Chemical Ratings

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Verification Status

How to read the GHS Hazard Summary Table

How to read the C2CC Hazard Summary Table